Effects of tetrandrine combined with acetylcysteine on exercise tolerance, pulmonary function and serum TNF-β1 and MMP-7 in silicosis patients
Identifieur interne : 000164 ( an2020/Analysis ); précédent : 000163; suivant : 000165Effects of tetrandrine combined with acetylcysteine on exercise tolerance, pulmonary function and serum TNF-β1 and MMP-7 in silicosis patients
Auteurs : Jing Zhang [République populaire de Chine] ; Yingchun Wang [République populaire de Chine] ; Shujuan Zhang [République populaire de Chine] ; Jing Li [République populaire de Chine] ; Hong Fang [République populaire de Chine]Source :
- Experimental and Therapeutic Medicine [ 1792-0981 ] ; 2020.
Abstract
The aim of the study was to investigate the effects of tetrandrine combined with acetylcysteine on exercise tolerance, pulmonary function, transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase 7 (MMP-7) in silicosis patients. A retrospective analysis was performed on 149 silicosis patients admitted to the Maternal and Child Health Care Hospital of Zhangqiu District between August, 2015 and September, 2017. Of the 149 patients, 70 patients treated with acetylcysteine comprised the control group, and 79 treated with tetrandrine combined with acetylcysteine constituted the study group. The concentrations of serum TGF-β1 and MMP-7 before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA), and the exercise tolerance and pulmonary function were compared. Chest distress, chest pain, cough, expectoration and dyspnea in the two groups were relieved after treatment, and the improvement rates of chest distress, chest pain and dyspnea in the study group were significantly higher than those in the control group (P<0.05). Before treatment, there was no significant difference in the results of the 6-minute walk test (6MWT) between the two groups (P>0.05). After treatment, the 6MWT in the two groups was significantly increased (P<0.05), and the improvement effect in the study group was more marked than that in the control group (P<0.05). There was no significant difference in the pulmonary function indexes between the two groups before treatment (P>0.05). Before treatment, there was no significant difference in serum TGF-β1 and MMP-7 expression levels between the two groups (P>0.05). By contrast, after treatment, the levels in the two groups were significantly decreased, with the levels in the study group being significantly lower than that the control group (P<0.05). In conclusion, tetrandrine combined with acetylcysteine can improve pulmonary function and exercise tolerance of patients with silicosis by inhibiting the expressions of TGF-β1 and MMP-7, thus improving clinical efficacy.
Url:
DOI: 10.3892/etm.2020.8431
PubMed: 32104284
PubMed Central: 7027229
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pharmacy, Maternal and Child Health Care Hospital of Zhangqiu District, Jinan 250200</wicri:regionArea><wicri:noRegion>Jinan 250200</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yingchun" sort="Wang, Yingchun" uniqKey="Wang Y" first="Yingchun" last="Wang">Yingchun Wang</name><affiliation wicri:level="1"><nlm:aff id="af2-etm-0-0-8431">Department of Pharmacy, Yantaishan Hospital, Yantai 264000, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pharmacy, Yantaishan Hospital, Yantai 264000</wicri:regionArea><wicri:noRegion>Yantai 264000</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shujuan" sort="Zhang, Shujuan" uniqKey="Zhang S" first="Shujuan" last="Zhang">Shujuan Zhang</name><affiliation wicri:level="1"><nlm:aff id="af3-etm-0-0-8431">Occupational Disease Department, Branch of Tai'an City Central Hospital, Tai'an 271000, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Occupational Disease Department, Branch of Tai'an City Central Hospital, Tai'an 271000</wicri:regionArea><wicri:noRegion>Tai'an 271000</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jing" sort="Li, Jing" uniqKey="Li J" first="Jing" last="Li">Jing Li</name><affiliation wicri:level="1"><nlm:aff id="af4-etm-0-0-8431">Department of Surgery, The People's Hospital of Zhangqiu Area, Jinan 250200, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Surgery, The People's Hospital of Zhangqiu Area, Jinan 250200</wicri:regionArea><wicri:noRegion>Jinan 250200</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Hong" sort="Fang, Hong" uniqKey="Fang H" first="Hong" last="Fang">Hong Fang</name><affiliation wicri:level="1"><nlm:aff id="af5-etm-0-0-8431">Department of Hepatobiliary Surgery, Weifang Traditional Chinese Hospital, Weifang 261041, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Hepatobiliary Surgery, Weifang Traditional Chinese Hospital, Weifang 261041</wicri:regionArea><wicri:noRegion>Weifang 261041</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental and Therapeutic Medicine</title><idno type="ISSN">1792-0981</idno><idno type="eISSN">1792-1015</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The aim of the study was to investigate the effects of tetrandrine combined with acetylcysteine on exercise tolerance, pulmonary function, transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase 7 (MMP-7) in silicosis patients. A retrospective analysis was performed on 149 silicosis patients admitted to the Maternal and Child Health Care Hospital of Zhangqiu District between August, 2015 and September, 2017. Of the 149 patients, 70 patients treated with acetylcysteine comprised the control group, and 79 treated with tetrandrine combined with acetylcysteine constituted the study group. The concentrations of serum TGF-β1 and MMP-7 before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA), and the exercise tolerance and pulmonary function were compared. Chest distress, chest pain, cough, expectoration and dyspnea in the two groups were relieved after treatment, and the improvement rates of chest distress, chest pain and dyspnea in the study group were significantly higher than those in the control group (P<0.05). Before treatment, there was no significant difference in the results of the 6-minute walk test (6MWT) between the two groups (P>0.05). After treatment, the 6MWT in the two groups was significantly increased (P<0.05), and the improvement effect in the study group was more marked than that in the control group (P<0.05). There was no significant difference in the pulmonary function indexes between the two groups before treatment (P>0.05). Before treatment, there was no significant difference in serum TGF-β1 and MMP-7 expression levels between the two groups (P>0.05). By contrast, after treatment, the levels in the two groups were significantly decreased, with the levels in the study group being significantly lower than that the control group (P<0.05). In conclusion, tetrandrine combined with acetylcysteine can improve pulmonary function and exercise tolerance of patients with silicosis by inhibiting the expressions of TGF-β1 and MMP-7, thus improving clinical efficacy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Yuan, J" uniqKey="Yuan J">J Yuan</name></author><author><name sortKey="Yao, S" uniqKey="Yao S">S Yao</name></author><author><name sortKey="Jin, Y" uniqKey="Jin Y">Y Jin</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author><author><name sortKey="Tian, W" uniqKey="Tian W">W Tian</name></author><author><name sortKey="Xi, J" uniqKey="Xi J">J Xi</name></author><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name></author><author><name sortKey="Weng, D" uniqKey="Weng D">D Weng</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J 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uniqKey="Pardo A">A Pardo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name></noRegion><name sortKey="Fang, Hong" sort="Fang, Hong" uniqKey="Fang H" first="Hong" last="Fang">Hong Fang</name><name sortKey="Li, Jing" sort="Li, Jing" uniqKey="Li J" first="Jing" last="Li">Jing Li</name><name sortKey="Wang, Yingchun" sort="Wang, Yingchun" uniqKey="Wang Y" first="Yingchun" last="Wang">Yingchun Wang</name><name sortKey="Zhang, Shujuan" sort="Zhang, Shujuan" uniqKey="Zhang S" first="Shujuan" last="Zhang">Shujuan Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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